Which of the following situations is not an indication for PrEP?

Pre-exposure prophylaxis (PrEP) is a preventive strategy for individuals at high risk of contracting HIV. Each option presented indicates different risk factors that might warrant the use of PrEP.

In the case of sexual assault, it is important to note that while this is a critical situation requiring immediate medical attention and appropriate care—including post-exposure prophylaxis (PEP) if applicable—PrEP is not designed as a response for assault instances. PrEP is meant for individuals who are at ongoing risk of HIV exposure through regular sexual activity, not for acute situations or isolated incidents such as sexual assault, which necessitates a different approach and management.

On the other hand, regular sexual activity with an HIV-positive partner, having multiple sexual partners, and being in sexual relationships with an HIV-negative partner may signify ongoing risk factors for HIV transmission, thus indicating the need for PrEP to help prevent infection in those contexts. This focus on risk assessment allows healthcare providers to determine the most appropriate preventive measures for their patients.